Detecting Metabolic Disease Before Symptoms Begin
Kihealth Labs is pioneering a molecular diagnostics platform designed to evaluate beta cell biology and the underlying disease processes driving Type 1 and Type 2 diabetes before traditional clinical markers become abnormal.
may be living with prediabetes.
are progressing toward Type 2 diabetes.
before traditional testing detects disease.
of diabetes and its complications each year.
Sources: CDC · International Diabetes Federation
The Metabolic Disease Crisis
Metabolic disease is one of the largest and fastest-growing healthcare challenges in the world, yet most patients are identified only after significant biological damage has already occurred.
- Stage 01
Healthy Metabolism
Insulin signaling intact · glucose tightly regulated
—Baseline biology
- Stage 02
Insulin Resistance
Cells become less responsive · beta cells compensate
~1 in 3U.S. adults with prediabetes (CDC)
- Stage 03
Beta Cell Stress
Chronic overproduction strains pancreatic islet cells
~80%of prediabetes is undiagnosed (CDC)
- Stage 04
Beta Cell Death
Cellular apoptosis begins · function silently erodes
Yearsof damage before clinical detection
- Stage 05
Prediabetes
Glucose dysregulation emerges · still reversible
537Mpeople living with diabetes globally (IDF)
- Stage 06
Type 2 Diabetes
Clinical thresholds crossed · diagnosis confirmed
~240Mpeople living with undiagnosed diabetes (IDF)
- Stage 07
Complications
Cardiovascular, renal, neurological, retinal injury
$1T+estimated annual global cost of diabetes
What if we could evaluate disease biology earlier?
At the center of metabolic disease — the beta cell.
The health of a single cell type — the pancreatic beta cell — defines whether a patient stays metabolically well, or doesn't.
The Life Cycle of a Beta Cell.
Beta cells sit at the center of metabolic disease. Their health, their stress, and their loss define the trajectory of every patient who develops diabetes. Explore each stage of their lifecycle below.
Healthy Beta Cell
Pancreatic islets are densely populated with insulin-secreting beta cells. Glucose sensing, insulin synthesis, and secretion operate in coordinated balance.
Illustrative model of beta cell decline. Not for diagnostic use.
A blood draw, decoded.
Six tightly-coupled stages turn a single tube of plasma into a quantitative readout of active beta-cell biology.
The InterceptIQ pipeline is a continuous instrument loop. Every stage is quality-controlled, traceable, and engineered to preserve fragmentomic detail from picogram-level input through clinical reporting.
One platform.
Many applications.
InterceptIQ™ generates biological intelligence across prevention, clinical care, therapeutic innovation, and population health.
Population Screening
Identify metabolic risk earlier across communities and systems.
Clinical Trials
Stratify and monitor patient populations for therapeutic development.
GLP-1 Monitoring
Quantify biological response to GLP-1 and metabolic therapies.
Functional & Longevity
Evaluate metabolic health through a root-cause clinical lens.
Pediatric Diabetes
Support pediatric Type 1 diabetes screening and monitoring.
Employer Programs
Power workforce health and preventative initiatives at scale.
Built on academic rigor.
Multi-center cohorts, leading institutions, and a growing body of peer-reviewed evidence — the foundation beneath every result Kihealth returns.
View the full validation dashboardAcademic partners
Clinical sites
Patient samples
Publications & posters
A trusted network of leading institutions.
Multi-center collaborations with the academic and clinical organizations defining the future of metabolic health.
From Yale discovery to global platform.
Kihealth's science traces directly to foundational Type 1 diabetes research at Yale — translated, protected, and engineered into a commercial diagnostics platform.
- YaleFoundational researchBeta cell cfDNA biology — Herold Lab
- DiscoveryScientific platformMethylation atlas validated
- IPPatent protection7+ patent assets secured
- ClinicalMulti-center validationTEDDY · DAISY · Nemours · UF
- TodayCommercial platformInterceptIQ™ in market
- GlobalExpansionPartnerships & programs worldwide
Disease interception, years earlier.
Partner with Kihealth to bring metabolic intelligence to clinicians, pharmaceutical programs, and the patients waiting on better answers.